Matrix Metalloproteinase 13. Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II col ….
MMP adalah keluarga besar protease dikenal sebagai superfamili metzincin. Secara kolektif, enzim ini mampu mendegradasi semua jenis protein matriks ...
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Neostatins are MMP-derived cleavage products of collagen-XVIII. Neostatin-7 is a C-terminal 28 kDa endostatin-spanning fragment generated from collagen-XVIII by MMP-7 . MMP-14 (also known as MT1-MMP) generates 23 kDa neostatin-14 from collagen-XVIII . Murine neostatin-7 inhibits calf pulmonary artery EC proliferation.
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